This is the ultimate buyer’s guide to the Best Enzyme Drain Cleaners. We’ve listed our top picks, including the Most popular, Top-rated, and Bestselling Products.
After hours of scanning and analyzing the market, using too many factors, we have found the Best Enzyme Drain Cleaners of 2022. Check out our ranking below!


Top 20 Best Enzyme Drain Cleaners of 2022



Best Enzyme Drain Cleaners 2022 (Reviews)


Green Gobbler ENZYMES for Grease Trap & Sewer - Controls Foul Odors & Breaks Down Grease, Paper, Fat & Oil in Sewer Lines, Septic Tanks & Grease Traps (1 Gallon)

$19.98  in stock
3 new from $19.98
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • RAPID DEGRADATION TECHNOLOGY. Green Gobbler Enzyme Drain Cleaner degrades fats, oils, greases, starches, proteins, cellulose, sludge, and other food waste. Enzymes are a safer alternative to sodium hydroxide and other caustic chemicals.
  • REDUCE PUMP-OUT FREQUENCY. Enzyme Drain Cleaner reduces the frequency of costly septic tank pump outs when used regularly. Increases the efficacy of grease traps by allowing bacteria to work more effectively.
  • TARGETS FOG, EVEN AS pH DECREASES. Green Gobbler Enzyme Drain Cleaner aids in the biological breakdown of organic material inside of drains and tanks. Promotes separation of water phase from FOG phase, thanks to de-emulsifying surfactant.
  • ULTRA-FAST ODOR ELIMINATION. Green Gobbler Enzyme Drain Cleaner eliminates odors associated with drain lines, lift stations, sewers, septic tanks, leach fields, cesspools, grease traps, and grease interceptors.
  • GUARANTEED, OR YOUR MONEY BACK. Green Gobbler’s conscious creations are safer, stronger, and more effective than caustic chemicals. 30-day money back guarantee. Your satisfaction is guaranteed.

AmazonCommercial Multi-Purpose Enzyme Cleaner, 1-Gallon, 1-Pack

$19.49  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • 1 gallon bottle of multi-purpose enzyme cleaning solution for a wide variety of surfaces and environments
  • Breaks up complex organic proteins, pet smells and stains, hair, grease, oils, and more for effective results
  • Ideal for commercial properties, retail, and hospitality
  • Use as needed on stains and problem areas for spot cleaning carpet, surfaces, drains, toilets, grease traps, and more
  • Non-corrosive, non-flammable, non-acidic, and non-caustic with a fresh mint scent

Zep Drain Defense Enzymatic Drain Cleaner Powder 18 Ounces (Case of 2) ZDC16 - Safe for Pipes and Septic Systems

$20.99
$19.94
 in stock
7 new from $19.93
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • Helps prevent clogs in sinks, toilets and showers
  • ENZYME BASED FORMULA: Breaks down drain-clogging elements. Use monthly to prevent future clogs from happening
  • SAFE FOR: PVC and most other septic systems
  • Certified, biodegradable formula, breaks down into carbon dioxide, minerals and water
  • BREAKS DOWN: Into CO2, minerals and water

Green Gobbler BIO-Flow Drain Strips - 24 Strips | Drain Cleaner & Deodorizer

$12.99
$9.98
 in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • ULTRA CONCENTRATED strips for powerful cleaning and deodorizing of household drain lines. Smelly drain? Bio-Flow Drain Strips will eat away at organic matter better than the no-name drain cleaner you have under your sink. Drop one strip into your drain and the slow-dissolving bacteria and enzymes will start to work instantly.
  • ELIMINATES & DIGESTS grease, oil, fats, scum and food quickly for easy drain cleaning. The gunk that’s stuck inside of your drain won’t stand a chance against Bio-Flow’s enzymes. Grease, oil, fats, scum, food: all gone in a matter of minutes. How’s that for easy drain maintenance?
  • UTILIZES POWERFUL YET SLOW DISSOLVING enzymes to take care of lodged organic materials. Food and grease will stick to your drain like Velcro. Pretty gross. Luckily you can clear the gunk in your drain with a Bio-Flow Deodorizing Strip.
  • SAFE ON ALL PIPES and septic systems (including old pipes and PVC pipes)
  • PERFECT AS PART of a monthly drain cleaning routine. Traditional Use: Once a month, drop one Bio-Flow strip into the drain for cleaning and deodorizing. Perfect for kitchen and bathroom drains.

Zeiff Pro-Grade Multi-Purpose Enzyme Cleaner - Powerful Cleaning & Odor Eliminating Formula For Professional & Home Surfaces - 1 Gallon - Fresh Breeze

$20.97
$18.87
 in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • Pro Grade Clean - Zeiff Pro-Grade Formulas are innovative, unique proprietary solutions, trusted by professionals and consumers for being the most effective cleaning products to get the job done. Whether you’re a pro or just expect pro-grade results, Zeiff delivers Pro Grade Clean
  • Powerful Cleaning Performance - Our proprietary formulation breaks up complex organic proteins, pet stains, hair, grease, fats, and oils, easily cutting through dirt, grease and grime without leaving any visible residue. Don't just expect clean, expect Zeiff Clean! You'll know it when you see it, clean you didn't even know exists
  • Multi-Purpose Enzyme Cleaner - The special blend of bacterial enzymes, detergent and deodorant, prevents clogging in drains, grease traps, septic tanks, drain lines and downpipes, and cleans stains, odors, carpets, floors, kitchen & bathroom surfaces, and much more. Ideal for Professional and Home use
  • Deodorizer & Odor Eliminator - Highly concentrated bacterial digestant for grease, stains, oils, & organic waste. Effectively eliminates foul odors caused by urine, feces, blood, vomit, food, garbage and grease, leaves long-lasting freshness, with a subtle fresh breeze that instantly refreshes any space with a pleasant aroma
  • Safe & Effective - Zeiff Pro Grade Formulas are safe & effective, non-corrosive, non-flammable, non-acidic, free of caustics and dyes, pH neutral, paraben-free, pet safe, cruelty-free. Proudly made in the USA

Biokleen Bac-Out Drain Cleaner - 32 Ounce - Deodorizes, Prevents Clogs, Eco-Friendly, Non-Toxic, Live Enzyme-Producing Cultures and Plant Extracts, No Artificial Fragrance or Preservatives

$8.99  in stock
2 new from $8.99
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • PREVENTS DRAIN CLOGS AND ELIMINATES ODORS: Bac-Out Drain Care prevents clogs, and eliminates tough odors. Its gel coating action thoroughly coats pipes to treat slow drains
  • KEEPS PETS AND KIDS IN MIND: Bac-Out Drain Care leaves no harsh fumes or residue, just cleaner pipes and less odor.
  • BIO-ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT-BASED PRODUCT: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • NEVER TESTED ON ANIMALS AND MADE IN THE USA: Biokleen products are never tested on animals, use biodegradable ingredients and are proudly manufactured in America

SANI 360° Sani Sticks Drain Cleaner and Deodorizer | Non-Toxic, Enzyme Formula to Eliminate Odors and Helps Prevent Clogged Drains | Septic Tank Safe | 48 Count, Lemon

$14.99  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • SMART CLEANING: Sani Sticks cleaner, deodorizer and clog preventer are a powerful, safe and efficient way to eliminate embarrassing, foul odors from drains and helps to prevent clog backups in sinks and showers. Its non-toxic formula is gentle and safe on septic tanks and is available in multiple scents and count varieties.
  • SMART CLEANING: Sani Sticks cleaner, deodorizer and clog preventer are a powerful, safe and efficient way to eliminate embarrassing, foul odors from drains and helps to prevent clog backups in sinks and showers. Its non-toxic formula is gentle and safe on septic tanks and is available in multiple scents and count varieties.
  • ONE STICK IS ALL IT TAKES: Made with powerful, natural enzymes, each Sani Stick slowly releases a super concentrated blend of powerful enzymes that will eliminate organic deposits and grease build up for 30 days. Just one Sani Stick a month is all that is needed.
  • INNOVATIVE DESIGN: Sani Sticks drain deodorizer and cleaners are thin, cylindrical and only 6.3 inches long making them ideal for homes and businesses. 100% safe for all types of plumbing, the stick rests in the pipe-trap and slowly releases a blend of enzymes that break down food, grease, oil and other organic materials.
  • SAFE TO USE ANYWHERE: Because these odor eliminating drain sticks are non-toxic and use enzymes to clean, they are safe to use in all drains from the bathroom to the kitchen.

Earthworm Drain Cleaner - Drain Deodorizer - Natural and Family-Safe - 64 fl oz

$19.49  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • Great For All Slow Running Drains,Sinks,Garbage Disposals-Safe and Effective.
  • Liquid Drain Cleaner/Opener, No harsh chemical residues; safer for children and pets.
  • Citrus & sage fragrance, keeping your drains smelling fresh.
  • Removes build-up and helps stop clogs before they start.
  • Natural enzymes won't damage plumbing.

Probiotic Enzyme Cleaner - Professional Strength Solution -One Gallon- Natural Bio-Enzymatic Stain & Odor Remover - Plant Based, Safe, Multi-Purpose/Surface Eliminator: Floors, Laundry, Drain, Carpet; Urine, Wine, Smoke, Vomit, Coffee - No Rinse Formula - Dye Free (Gallon - 128oz)

$19.95  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • ENZYME ACTIVATED: Our enzymatic formula contains natural live cultures that seek & destroy organic waste as a food source. Releasing powerful enzymes to break down complex compounds for the probiotics to consume, they remain active for up to 80 hrs, continuing to work against new soils & odors as they emerge. Unlike traditional chemical-based products, these probiotics penetrate small cracks & grout, eliminating stains & odors. Simply spray & let the probiotics do the dirty work!
  • THE SCIENCE: Enzymes work to break down complex waste particles into smaller pieces that can be more easily consumed. These smaller particles—organic wastes, urine, grease, stains—become “food” for Probiotics to digest and break down into two basic compounds—carbon dioxide (CO2) and water (H2O).
  • READY TO USE & NO RESIDUE: Commercial-grade, maximum strength formula provides fast-acting, sustained stain & odor elimination that’s RELIABLE & EASY. No need to measure, mix, or dilute; just saturate and give your hungry Bio-Enzyme army time to eat. With safe ingredients, rinsing is not necessary. Bastion will not leave behind any haziness, film, streaks, stickiness, buildup, or residue. All you’ll have is a clean, odor-free environment - without that nasty using dangerous and harsh chemicals.
  • MULTI-SURFACE: Formulated for efficiency & versatility, Bastion’s Probiotic Stain & Odor Remover can be used on hard surfaces, floors, carpets, fabric, laundry, drains, grease traps, toilets, septic tanks, & more, to effectively eliminate stains and odors at their source. Designed to rapidly destroys organic soils and rid odors completely and permanently so they never return, Bastion is your #1 solution for cleaning grease, food stains, wine, coffee, urine, feces, blood, and vomit.
  • FAMILY SAFE & ENVIRONMENTALLY FRIENDLY: Bastion Probiotic Stain & Odor Remover contains neither bleach nor chlorine. This product is non-toxic and hypoallergenic, making it safe for your children, pets, home, and the planet. With its water-based formula, it’s tough on stains & odors, while gentle on people and objects. Use it freely around your home with peace of mind and enjoy the fresh & clean environment that Bastion provides.

Biokleen Bac-Out Enzymatic Drain Cleaner - 32 Ounce (2 Pack) - Enzyme Prevents Clogs, Eco-Friendly, Live Enzyme-Producing Cultures and Plant Extracts, No Artificial Fragrance or Preservatives

$17.98  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • PREVENTS DRAIN CLOGS AND ELIMINATES ODORS: Bac-Out Drain Care prevents clogs, and eliminates tough odors. Its gel coating action thoroughly coats pipes to treat slow drains
  • KEEPS PETS AND KIDS IN MIND: Bac-Out Drain Care leaves no harsh fumes or residue, just cleaner pipes and less odor.
  • BIO-ACTIVE FORMULA: A unique blend of live enzyme cultures breakdown and absorb organic material. It's a more natural way to remove buildup and stinky odors.
  • PLANT-BASED PRODUCT: Bac-Out uses a plant-based, eco-friendly solution with no artificial fragrances or dyes. Our products never contain phosphates, chlorine, ammonia, or brighteners.
  • NEVER TESTED ON ANIMALS AND MADE IN THE USA: Biokleen products are never tested on animals, use biodegradable ingredients and are proudly manufactured in America

48PCS Drain Cleaner Sticks Sink Deodorizer Clog Remover Organic Enzyme Drain Cleaner Tank Safe Prevent Expensive Sewage Backups for Kitchen Bathroom Toilet Showers

$30.99
$13.99
 in stock
2 new from $7.99
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • 【BRAND EFFECT BUT COST-EFFECTIVE】Exactly the same unclog effect as the brand as seen on TV but more cost-effective. Achieve a fresh smelling drain and avoid the smell with scented drain cleaner sticks, a toxic-free, affordable, user-friendly methods to effectively prevent clogs, dispel unpleasant smell as well as stop clog backups and improve water flow in drains. Ease of use, and low cost.
  • 【BIODEGRADABLE & NATURAL】Perfect for the kitchen sinks, vanity, bathtub, toilet, showers, etc.
  • 【ONE STICK PER MONTH IS OK】 Each drain pipes takes only one cleaner stick measures 6.3 inches strip of organic enzymes. Once been applied, these enzymatic drain cleaners can keep effective as long as one month as they work. Comes in packs of 48, enough for a family use for an entire year. Use it regularly so that keep your kitchen and bathroom drains running smoothly.
  • 【SAVE HUNDREDS OF DOLLARS】Drain cleaner sticks are surely help reduce plumbing costs in a simple, sanitary, yet effective way. Say goodbye to high plumbing costs and the hassle of of using a snake or other devices. Just a couple of dollars, you’ll get excellent clogs removers as well as deodorizers of 3 kind of scents, to help unclog the drains and freshen up your house.
  • 【RELIABLE AFTER SALE SERVICE】 If you don't have a positive experience for ANY reason, we will do WHATEVER it takes to make sure you are 100% satisfied with your purchase, and we want to make sure we back that up with a risk free ironclad 30-Day Money Back and Ready to Respond within 24 hours.

Drain Sticks Drain Stix DrainStix Drain Cleaner Deodorizer Sticks Flexible Non-Fragile for Preventing Clogs Eliminating Smelly Odor Enzyme Kitchen Bathroom Sink Septic Tank Safe As Seen On TV (48)

$9.99  in stock
3 new from $9.99
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • ❤2020 NEW UPGRADED POWERFUL ENZYME: 2020 new drain sticks slowly release powerful enzyme in the drain, to prevent future clogs and eliminat smelly odors effectively. The powerful enzymes can break down grease, fats, oils, soap scum and food to keep the sink clean, eliminating embarrassing odor from drains to keep your drains clean and odor-free all year long with Drain Sticks. Save your money on plumbers and drain snakes.
  • ❤FLEXIBLE & MORE EFFECTIVE: The Upgraded drain stix is Flexible and Non-fragile, they won't be broken during transportation. So they can be long enough to stay in the U-shape pipe but not be washed away. The enzyme cleaning action could continuously effect to break down organic deposits and grease buildup, keep your drains free flowing.
  • ❤SUITABLE FOR ALL DRAIN PIPES: The Drain Stix for clogs and odors can be used in both plastic and metal drain pipes, 100% safe for home kitchen, vanity, bathtub, shower, wash basin and toilet bowl sewer drainage outlet. 100% safe for septic tank, too.
  • ❤SAFE, NON-TOXIC & CONVENIENT TO USE - The drain stix is unstained and undyed, it is health product for household, no need to worry about they will hurt your health. The drain sticks are passed by SDS test, safe to use in home. The dimension of drain sticks is suitable for most of drains, you can just drop one piece in one drain per month and do not need any other actions. Then drain sticks can clean drains automatically, save your money and save your time.
  • ❤24x7 Hours Support: Our mission is to offer great and helpful products to customers, and we offer 24x7 hours support. If you have any issue about our drain sticks, please kindly send us information via Buyer-Seller Message, we will reply in 8 hours and help you solve any problems.

Black Diamond Stoneworks GET SERIOUS Grease Trap Treatment Commercial Enzyme Drain Opener, Cleaner, Odor Control, Trap Cleaning and Maintenance.

$32.98
$24.98
 in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • PROFESSIONAL STRENGTH Grease Trap Cleaner and Commercial drain opener.
  • SAVE MONEY & REPAIRS with GET SERIOUS Grease trap Treatment.
  • COMMERCIAL DRAIN CLEANER for slow draining sinks and lines. Keeps Grease Traps & Drains Flowing
  • ENZYME DRAIN OPENER cleans the pipes before the grease trap, grease trap & pipes leaving the trap.
  • ELIMINATES OFFENSIVE ODORS Safe on Pipes & Plumbing.

DrainScrub Powder Enzyme Drain Cleaner and Septic Treatment Environmentally Friendly Bacteria Unclog and Deodorize Pipes (2 lbs)

$49.95  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • 100% Natural Bacteria and Enzymes Blasts Away Clogs and Odors
  • Environmentally Friendly Microbes will not Harm Pipes - Plumber Recommended
  • Satisfaction Guaranteed - Made in the USA
  • Double Strength - Contains Double the Bacteria and Enzymes of Industry Leading Products
  • Packed with Micronutrients for Better Results

Green Gobbler BIO-FLOW Drain Strips | 12 Pack | Drain Cleaner Sticks

$6.46  in stock
2 new from $6.46
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • ELIMINATES & Prevents Foul Odors!
  • KEEPS DRAINS Free Flowing!
  • USE ON: Sinks, Tubs, Floor Drains, Garbage Disposals & More!
  • 100% Septic Safe! Great For Kitchens, Bathrooms & Laundry Rooms.
  • BREAKS DOWN Grease, Fats, Oils, Soap Scum, Food & Organic Build up!

Earthworm Fragrance Free Drain Cleaner - Drain Opener - Natural Enzymes, Environmentally Responsible, Safer for Pets and Kids - 1 Half Gallon, 64 oz

$19.48  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • Does not contain harsh chemicals
  • Natural Enzymes won't damage plumbing
  • Removes build-up & helps stop clogs before they start
  • Keeps drains & garbage disposals smelling clean and fresh!
  • Fragrance Free

Instant Power 1510 Commercial Drain Cleaner, 1-Gallon

$14.98  in stock
4 new from $14.98
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • Reduces fat, oil & grease build-up in drains
  • Reduces grease trap pumping
  • Eliminates odors
  • Treats kitchen and restroom drains, plus grease traps

BioFresh - Enzyme Drain Cleaner & Odor Eliminator. Deodorizes and Unclogs Smelly Garbage Disposals, Washing Machines and Slow Drains. Super Concentrate w/Pleasant Fragrance (32oz)

$24.95  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

Part Number86458900017
Size32oz

Drain Sticks Drain Cleaner Sticks Drain Deodorizer Sticks for Preventing Clogs Eliminating Smelly Odor Kitchen Bathroom Sink Septic Tank Safe As Seen

$12.99
$10.74
 in stock
4 new from $10.74
Free shipping
Amazon.com
as of February 27, 2022 12:53 am

Features

  • ❤Effective For Preventing Future Clogs and Eliminating Smelly Odor (Can not cleaning badly clogged drains): The Drain Sticks are effective drain deodorizer and cleaner, it has powerful enzymes those can break down grease, fats, oils, soap scum and food to keep the sink clean, eliminating embarrassing odor from drains to keep your drains clean and odor-free.All year long with Drain Sticks. Save your money on plumbers and drain snakes.
  • ❤SUITABLE FOR DIFFERENT DRAIN PIPES: The Drain Stix for clogs and odors can be used in both plastic and metal drain pipes, 100% safe for home kitchen, vanity, bathtub, shower, wash basin and toilet bowl sewer drainage outlet.
  • ❤SAFE & NON-TOXIC - Lipase, amylase, protease. The drain stix is unstained and undyed, is health product for household, no need to worry about then will hurt your health. Safe products for Green House.
  • ❤CONVENIENT TO USE: The drain deodorizer stick is thin, round and 3.94 inches long only. This dimension is suitable for any style of U shape drains. You can just drop it in any drains in your home and don't need any other actions. It will dissolve by itself. Just drop 1pc Drain Stick in one drain per month as the effect can last for one month. Easy for use and easy for store.
  • ❤After-Sales Service: Our aim is to do our best to satisfy our customers with good shopping experience. If there is any issue, we are always here to solve it.

Bio-Clean Ultimate Drain Cleaning Kit Cleans Drains- Septic Tanks - Grease Traps All Natural and 100% Guaranteed No Caustic Chemicals! Removes fats Oil and Grease, Completely Cleans Your System.

$59.95  in stock
Amazon.com
as of February 27, 2022 12:53 am

Features

  • 100% All Natural Bacteria Enzymes
  • All The Tools You Need In One Convenient Box
  • Guaranteed To Fix Slow Running Drains!
  • Environmentally friendly and safe
  • Free Shipping

Best Enzyme Drain Cleaners 2022 | Price Comparison

How does the ranking system work?

Our app considers products features, online popularity, consumer reviews, consumer ratings, brand reputation, prices, and many more factors, as well as reviews by our experts. read more About Us

Your Guide To Buying The Best Enzyme Drain Cleaners

Worried about buying the Best Enzyme Drain Cleaners? Your doubts are gone.
We understand this because we have already gone through the entire process of researching the best products.
So we have compiled a complete list of the “Best Enzyme Drain Cleaners” available on the market today.

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  1. Read reviews of your chosen product, and what consumers are saying,
  2. Select the right brand of the Best Enzyme Drain Cleaners, and
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  4. Select the features that satisfy your needs.

A thorough and thoughtful examination is essential to ensure that you get the “Best Enzyme Drain Cleaners” possible.
We provide guidance on buying the Best Enzyme Drain Cleaners, and this information is complete and accurate.
We use both artificial intelligence and big data to analyze the information we collect, using a selection of algorithms that have allowed us to compile a list of the Best Enzyme Drain Cleaners currently available on the market.
This is the technology we use to compile our list based on a variety of factors, we always remember that keeping the Best Enzyme Drain Cleaners information up-to-date is the most important thing, so we are constantly updating our site.

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